Many families have purchased Neprinol for their mother or father’s arthritis and now their memory has improved and nearly returned to normal. While they might call this improvement a miracle, it is not due to luck or divine intervention. It all comes down to Neprinol’s ability to dissolve the protein fibrin.

Fibrin is a protein that is naturally found in blood and is responsible for forming blood clots and scar tissue. Usually our bodies keep fibrin levels in check with enzymes that break down any excess fibrin. However, with age our bodies make fewer enzymes, allowing fibrin to build up. That can lead or contribute to many serious diseases, including Alzheimer’s.

The role of fibrin in Alzheimer’s

One of the causes of Alzheimer’s disease is the buildup of hard plaques between brain cells. These plaques are made up of a protein called beta-amyloid, which is a small fragment of a naturally produced brain protein called amyloid precursor protein. Beta-amyloid is usually broken down and eliminated, but this doesn’t occur as efficiently as we get older [1]. However, just having a lot of beta-amyloid doesn’t automatically lead to plaque development.

Around the brain is a barrier that stops anything harmful in the blood from entering the brain—called the blood-brain barrier. Studies have shown that age-related damage to the blood-brain barrier allows fibrin and other proteins to leak into the brain [2]. Once inside the brain, the fibrin joins with any beta-amyloid that is there to form clots. These clots obstruct blood flow and contribute to inflammation, damaging the brain and leading to the memory loss and other problems associated with Alzheimer’s [2-4].

Researchers have been studying fibrin as a potential way to treat Alzheimer’s. Scientists from Rockefeller University found that they could reduce inflammation and blood vessel damage in the brains of Alzheimer’s mice by decreasing the amount of fibrin in their blood with a natural enzyme [2,5]. A later study showed that breaking up fibrin reduced the amount of amyloid deposits found in the brain blood vessels of Alzheimer’s mice and also improved their memories [4].

Neprinol

Neprinol is a combination of nattokinase, an enzyme extracted from a popular Japanese fermented soybean food, and serrapeptase, an enzyme from silkworms, as well as several other enzymes. When these enzymes are introduced into the bloodstream, they work throughout the entire body, to break down fibrin and other proteins, like beta-amyloid. In one study, nattokinase was shown to effectively degrade beta-amyloid protein [6]. This is evidence that nattokinase is useful in improving the symptoms of Alzheimer’s disease due to its ability to help remove the beta-amyloid plaques in the brain.

Also, by clearing any other “garbage” from the blood, Neprinol greatly reduces the amount of stress on the immune system. When the blood is clean the immune system becomes less aggravated and inflammation levels drop. This also has a positive effect on Alzheimer’s since the disease is partly due to inflammation in the brain [7,8].

Despite the proof that decreasing fibrin and inflammation can reduce the symptoms of Alzheimer’s, Neprinol and other enzyme supplements have not yet been rigorously tested in humans for this purpose. Still, Neprinol customers report that it helps in their relatives with Alzheimer’s and the studies exist to explain how it works. With few supplements available that help with Alzheimer’s, Neprinol is a great option.

References:

1. Vinters HV, Wang ZZ, Secor DL. Brain parenchymal and microvascular amyloid in Alzheimer’s disease. Brain Pathol. 1996;6(2):179-195.
2. Paul J, Strickland S, Melchor JP. Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer’s disease. J Exp Med. 2007; 204(8):1999-2008.
3. Merkle DL, Cheng CH, Castellino FJ, Chibber BA. Modulation of fibrin assembly and polymerization by the beta-amyloid of Alzheimer’s disease. Blood Coagul Fibrinolysis. 1996;7(6):650-658.
4. Cortes-Canteli M, Paul J, Norris EH, et al. Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer’s disease. Neuron. 2010;66(5):695-709.
5. Deane R, Zlokovic BV. Role of the blood-brain barrier in the pathogenesis of Alzheimer’s disease. Curr Alzheimer Res. 2007;4(2):191-197.
6. Hsu RL, Lee KT, Wang JH, Lee LY, Chen RP. Amyloid-degrading ability of nattokinase from Bacillus subtilis natto. J Agric Food Chem. 2009;57(2):503-508.
7. Tuppo EE, Arias HR. The role of inflammation in Alzheimer’s. Int J Biochem Cell Bio. 2005;37:289-305.
8. Zotova E, Nicoll JAR, Kalaria R, Holmes C, Boche D. Inflammation and Alzheimer’s disease: relevance to pathogenesis and therapy. Alzheimers Res Ther. 2010;2:1.

Dr H. A. Nieper, Editor:

I informed you some years ago that Serrapeptase is apparently active in the cleaning of coronary arteries from occluding layers.  The results are so spectacular that even Tom Valentine reported on this progress in the US (DC) press after speaking to several parties here.

Serrapeptase is an enzyme produced by serratia bacteria living on silkworms.  With this enzyme the worms melt a hole out of the cocoon.  Unlike other enzymes in the field of biology, Serrapeptase dissolvesdead’ tissue like or e.g. not both silk and apparently also fibrinoid layers in the arteries which chemically could be compared to silk.

A special problem in today’s civilized society is occluding processes in the carotid arteries of the neck.  Very often we see patients where surgeons were reluctant to operate or to apply drill or laser technology such occluded carotids.  The reason for this is the potential risk that off coming debris will be pushed into the smaller cerebral vessels.

We have, therefore started to apply Serrapeptase in cases of severe narrowings of the carotid arteries.  Mostly in patients showing severe symptoms due to the narrowing, including amaurosis fugax (intermittent blindness).  The therapeutic results are excellent, certainly lifesaving.  It is, however, mandatory that the therapy be conducted for a very long time.  The first reliable results can be expected after 6-8 months.  Even after month 18, after the onset of the therapy, the patients are improving.

I have also found Serrapeptase to be an extraordinary substance for safety removing fibrous blockages from coronary arteries, particularly the carotid arteries found in the neck, which supply blood brain.  Serrapeptase is a natural enzyme produced by serratia bacteria living in silkworms.  Once the silkworm has completed its transformation into a moth, it uses this substance to “melt” a hole in its cocoon, so that it can escape.

The astonishing fact is that, unlike other biological enzymes, Serrapeptase affects only non-living tissue, like the silk cocoon.  This is the reason the butterfly is not harmed.  For our health purposes, Serrapeptase dissolves only dead tissues such as the old fibrous layers that clog the lining of our arteries and dangerously restrict the flow of blood and oxygen to the brain.  Because of this, Serrapeptase is extremely useful in keeping arterial deposits from building up again after angioplasty (a balloon technique used to clear an artery blockage) or coronary bypass surgery has been performed.

Very often, surgeons are reluctant or unable to open partially closed carotid arteries using laser surgery. They fear that resulting debris could be pushed into smaller connecting arteries and result in a stroke and possibly death.  In cases of severe arterial narrowing, I have used Serrapeptase with excellent, even life-saving results.  Many of my patients have shown significant improved blood flow through their previously constricted arteries, as confirmed by ultrasound examination.  Unfortunately, orthodox cardiologists do not employ this important method in their practices. To find out even more about the many benefits of serrapeptase please visit www.Serrapeptase.Org.

Dr H. A. Nieper
Head, Dept of Medicine
Paracelcus Klink am Silbersee Oertzeweg 24
38051 Langenhagen, Germany
0511-7782-54
Fax: 0511 7782 54